Publications

Note: The names of current or former Reed students appear in bold type.

Peer-reviewed

Mellies, JL, Platenkamp, A, Osborn, J, and Ben-Avi, L. PerC Manipulates Metabolism and Surface Antigens in Enteropathogenic Escherichia coli. Frontiers in Cellular and Infection Microbiology, 07 February 2017

Xue, YOsborn, JPanchal, A, and JL Mellies. 2015. The RpoE Stress Response Pathway Mediates Reduction of Enteropathogenic Escherichia colivirulence by ZincApplied and Environmental Microbiology. 81: 3766-3774.

Winardhi RS, Gulvady R, Mellies JL, and Yan J. 2014. Locus of Enterocyte Effacement-Encoded Regulator (Ler) of pathogenic Escherichia coli competes off nucleoid structuring protein H-NS through non-cooperative DNA binding. Journal of Biological Chemistry. Mar 16. 289: 13739-13750.

Mellies JL, Thomas K, Turvey M, Evans NR, Crane J, Boedeker E, and Benison GC. 2012. Zinc-induced envelope stress diminishes type III secretion in enteropathogenic Escherichia coli. BMC Microbiology. Jun 24;12(1):123. [Epub ahead of print]

Mellies, JL, Benison, G, McNitt, WMavor, D, Boniface, C, and Larabee, FJ. 2011. Ler of Pathogenic Escherichia coli forms toroidal protein-DNA complexes. 2011. Microbiology 157: 1123-1133.

Mellies, JL, Larabee, FL, Zarr, MA, Horback, KL, Lorenzen, E and Mavor, D. 2008. Ler interdomain linker is essential for anti-silencing activity in enteropathogenic Escherichia coli. Microbiology. 154: 3624-3638.

Mellies, JL, Haack, KR, and DC Galligan. 2007. SOS regulation of the type III secretion system of enteropathogenic Escherichia coli. Journal of Bacteriology 189: 2863-2872.

Mellies, JL, Barron, A, and KR Haack, Korson, AS, and Oldridge, D. 2006. The global regulator Ler is necessary for EPEC colonization of the Caernorhabditis elegans. Infection and Immunity 74: 62-72.

Haack KR, CL Robinson, KJ Miller, JW Fowlkes and JL Mellies. 2003. Interaction of Ler at the LEE5 (tir) operon of Enteropathogenic Escherichia coli. Infection and Immunity 71: 384-292.

Mellies, JL, Navarro-Garcia, F, Frederickson, J, Nataro, JP and Kaper, JB. 2001. The espC pathogenicity island of enteropathogenic E. coli encodes an enterotoxin. Infection and Immunity 69: 315-324.

Sperandio, V, Mellies, JL, Delagay, RM, Frankel, G, Crawford, JA, Nguyen, W, and Kaper, JB. 2000. Activation of the enteropathogenic E. coli (EPEC) LEE2 and LEE3 operons by Ler. Molecular Microbiology 38: 781-793.

Elliott, SJ, Sperandio, V, Girón JA, Shin, Mellies, JL, Wainwright, L, Hutcheson, SW, McDaniel, T, and Kaper, JB. (2000) The locus of enterocyte effacement (LEE)-encoded regulator controls expression of both LEE- and non-LEE-encoded virulence factors in enteropathogenic and enterohemorrhagic Escherichia coli. Infection and Immunity 68: 6115-6126.

Sperandio, V, JL Mellies, W Nguyen, S Shin, and JB Kaper. 1999. Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli. 1999. Proceedings of the National Academy of Sciences USA 96:15719-15201.

Mellies, JL,Elliott, S, Sperendio, V, Donnenberg, MS and Kaper, JB. 1999. The Per regulon of enteropathogenic Escherichia coli: identification of a regulatory cascade and a novel transcriptional activator, the locus of enterocyte effacement (LEE)-encoded regulator, (Ler). Molecular Microbiology 33: 296-306.

Elliott, S, Dubois, MS, Hutcheson, SW, Mellies, JL, Wainwright, WA, Batchelor, M, Frankel, G, Knutton, S, and Kaper, JB. 1999. Identification of CesT, a chaperone for the type III secretion of Tir in Enteropathogenic Escherichia coli. Molecular Microbiology 33:1176-89.

Mellies, JL, Jose, J, and Meyer, TF. 1997. The Neisseria gonorrhoeae gene aniA encodes an inducible nitrite reductase. Molecular and General Genetics, 256: 525-532.

Mellies, JL, Rudel, T, and Meyer, TF. 1997. Transcriptional regulation of pilC2 of Neisseria gonorrhoeae: Response to oxygen availability and evidence for growth phase regulation in E. coli. Molecular and General Genetics, 255: 285-293.

Mellies, JL, Wise, A, and Villarejo, M. 1995. Two different Escherichia coli proP promoters respond to osmotic and growth phase signals. Journal of Bacteriology 177: 144-151.

Mellies, JL, Brems, R, and Villarejo, M. 1994. The Escherichia coli proU promoter element and its contribution to osmotically signaled transcription activation. Journal of Bacteriology 176: 3638-3645.

Reviews

Platenkamp, A, and Mellies, JL. Pathovar Transcriptomes. DOI: 10.1128/mSystems.00049-17.

Mellies, JL, and Lawrence-Pine, ER. 2010. Interkingdom Signaling between Pathogenic Bacteria and Caenorhabditis elegans. Trends in Microbiology 18: 448-454.

Mellies, JL, Barron, A, and AM Carmona. 2007. MiniReview: Enteropathogenic and Enterohemorrhagic Escherichia coli Virulence Gene Regulation. Infection and Immunity 75: 4199–4210.

Book Chapters

Mellies, JL, and E. Lorenzen. "EHEC Virulence Gene Regulation". In: V Sperandio and CJ Hovde (eds) "Enterohemorrhagic Escherichia coli" American Society for Microbiology, Washington, DC, 2015.

Mellies, JL, and Barron, A. “Virulence Gene Regulation in Escherichia coli” in EcoSal, an online publication from ASM Press.

Kaper, JB, Mellies, JL, and Nataro, JP. Chapter 3. "Pathogenicity Islands and Other Genetic Elements of Diarrheagenic Escherichia coli". In: J. Kaper, J. Hacker (eds) "Pathogenicity Islands and Other Mobile Virulence Elements" American Society for Microbiology, Washington, DC, 1999.

Patent

Infection Model For Developing Chemotherapeutic Agents. Patent No. 8,216,592 issued on July 10, 2012.