March 14th:
Discussion: PATRICK S. & Rachel

Wilkinson, M.B. Xiao, G., Kumar, A., LaPlant, Q., Renthal ,W., Sikder, D.,
Kodadek, T.J., and Nestle E.J. (2009) Imipramine Treatment and Resiliency Exhibit Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models. The Journal of Neuroscience, June 17, 2009 • 29(24):7820 –7832

For a review on Chromatin Modifications and Gene Expression Regulation see: Champagne FA. 2012. Interplay Between Social Experiences and the Genome: Epigenetic Consequences for Behavior  In Gene-Environment Interplay, pp. 33-57

If you find other useful papers, please bring them with you to class and share the wealth.

Who-s-Who: Rhea & Ryan
Food: Josh & Pia

Depression is a common debilitating illness that is actually a complex syndrome made up of multiple poorly defined subtypes. This paper models human sub-types of depression using inbred mice that exhibit two distinct responses to chronic defeat stress. They aim to characterize long-lasting changes in gene transcription within the nucleus accumbens in these two depression sub-types using the technique chromatin immunoprecipitation focused on differential histone modifications.

mouse