Schedule of Lecture Topics and Recommended Readings

DATE

TOPIC

TEXT READINGS*

Assignment

Due Date

WEEK 1

IN THE BEGINNING…

30-Aug What is Dev Bio & Fertilization I Chp 1;
Chp 9 pp. 342-348
Read syllabus and complete survey 1-Sep

1-Sep

Fertilization II and Cleavage

Chp 6 pp. 232-244

 

 

LAB FERTILIZATION & CALCIUM      

WEEK 2

DEVELOPMENTAL GENETICS and ORGANISMS

6-Sep Model organisms, genetic screens, and other dev bio methods Chp 2 pp. 35-40, 42
Chp 3 pp. 113-125
   
8-Sep Genetic regulation of embryo development Chp 10 pp. 368-382    

LAB

DEVELOPMENTAL GENETICS (FLIES)

Chp 2 p. 42; Chp 3 p. 120

Nüsslein-Volhard and Weischauss, 1980 Nature
Nüsslein-Volhard, 2012
Development

Lab notebook check

WEEK 3

AXIAL PATTERNING: MORPHOGENS & ORGANIZERS

13-Sep Lessons from flies Chp 2 pp. 40-66 What is a morphogen? 20-Sep
15-Sep Dorsal-ventral and left-right patterning (vertebrates like us) Chp 4 pp. 128-145    

LAB

(MIS)ORGANIZING MOLECULES (FISH)

 

Hashiguchi and Mullins, 2013 Development

 

WEEK 4

INDUCTION AND GASTRULATION

20-Sep Germ layers Chp 4 pp.145-172; Chp 5 pp. 173-186    
22-Sep Cell and Tissue movements (morphogenesis) Chp 8 pp. 289-315 Morphogenesis Q&A 27-Sep

LAB

GASTRULATION IN CLAY

 

Solnica-Kretzel and Sepich, 2012
Annu Rev Cell Dev Biol

Lab notebook check

WEEK 5

MECHANISMS OF MORPHOGENESIS

27-Sep Molecular, Cellular, and Environmental effects on shape Chp 8 pp. 289-315 FGF pathway detailed timeline 5 or 6 Oct
(in lab)
29-Sep EXAM #1      

LAB

SIGNALING PATHWAYS

pp. 184, 190, 192-3

 

14-Oct

WEEK 6

SEGMENTATION AND SOMITOGENESIS

4-Oct Clocks and Wavefronts Chp 5 pp 187-202 Yabe and Takada, 2016 Dev Growth
Differ
 
6-Oct Hox genes Chp 5 p 194 Hox gene regulation Q & A 11-Oct

LAB

SOMITOGENESIS & ORGANOGENESIS

 

 

25-Oct

WEEK 7

NEURULATION AND NERVOUS SYSTEM DEVELOPMENT I

11-Oct Neurulation and CNS development Chp 5 pp. 185-6; Chp 8 pp. 316-318
Chp 11 pp. 444-451; Chp 12
   
13-Oct Building a brain I      
LAB GENE EXPRESSION - in situ and immuno     notebook check

LAB

INDEPENDENT PROJECT
BRAINSTORM

 

 

rough draft
by 14-Oct

15-23 Oct FALL BREAK

WEEK 8

NERVOUS SYSTEM DEVELOPMENT II

25-Oct Building a brain II Chp 12 Repurposing Q&A 8-Nov
27-Oct Neural Crest & Peripheral Nervous System Chp 8, pp. 318-20;
Chp 10, pp. 389-92
   

LAB

INDEPENDENT PROJECTS

 

 

Final plan by 28-Oct

WEEK 9

MAKING LIMBS

     
1-Nov Limb development I Chp 11 pp. 411-444 Zeller et al., 2009 Nat
Rev Genet
 
3-Nov Limb development II Chp 11 pp. 411-444    

LAB

INDEPENDENT PROJECTS

 

 

notebook check

WEEK 10

MAKING TUBES

     
8-Nov Heart and Circulatory System Chp 11 pp. 451-467 Tubulation Q & A 15-Nov
10-Nov Lungs and Guts      

LAB

INDEPENDENT PROJECTS

 

 

 

WEEK 11

STEM CELLS AND DEVELOPMENT

     
15-Nov History of stem cells Chp 10 pp. 375-389 Mini-grant 1-Dec
17-Nov Organoids      

LAB

INDEPENDENT PROJECTS

 

 

 

WEEK 12

       
22-Nov EXAM #2      
24-Nov Thanksgiving      

LAB

INDEPENDENT PROJECTS

     

WEEK 13

HUMAN EMBRYOLOGY AND DEVELOPMENT

29-Nov Student Choice I TBD    
1-Dec Student Choice II TBD    

LAB

INDEPENDENT PROJECTS

 

   

WEEK 14

EVO-DEVO AND WRAP-UP

6-Dec Evo-Devo & Image Contest
Awards
Chp 15    

LAB

INDEPENDENT PROJECTS

 

 

notebook check

12-Dec

FINAL EXAM 1-4PM

 

oral presentations
and take-home exam